What medications interact with magnesium?
Magnesium binds several oral medications and reduces their absorption. The fix is timing: separate magnesium from levothyroxine, bisphosphonates, tetracycline/quinolone antibiotics, and certain HIV drugs by at least 4 hours.
Last updated 27 June 2026
Separate by at least 4 hours
Levothyroxine, tetracyclines (doxycycline, minocycline), fluoroquinolones (ciprofloxacin, levofloxacin), bisphosphonates (alendronate, risedronate), iron supplements, and some HIV antiretrovirals.
Medications that deplete magnesium
PPIs (omeprazole, esomeprazole) — long-term use, check levels yearly. Thiazide and loop diuretics. Some chemotherapy agents. Long-term metformin (mild effect).
Safe to take together
Statins, beta-blockers, ACE inhibitors, ARBs, SSRIs, anticoagulants — no clinically meaningful interaction; magnesium often helps tolerability.
Frequently asked
- What about HRT?
- No interaction — magnesium and HRT pair well.
- Vitamins together?
- Yes — magnesium pairs well with D3, K2, B-complex, and omega-3.
Educational content — not medical advice. Health claims comply with EU Regulation 1924/2006 and the Union Register of authorised claims (Regulation 432/2012). Food supplements are not a substitute for a varied, balanced diet and a healthy lifestyle. Always consult your GP or pharmacist before changing supplements, particularly if you take prescription medication or have kidney disease.